The Western Diet–Microbiome-Host Interaction and Its Role in Metabolic Disease
A high intake of ultra-processed foods is strongly associated with obesity and related metabolic diseases, but biological mechanisms supporting these associations have been largely unknown. This review aimed at elucidating how ultra-processed foods negatively affect host-microbiome-interactions, that in turn drive immune-derived metabolic aberrations resulting in health problems.
Publisert i Forskningspublikasjoner Mandag 4. oktober, 2021 - 13:42 | sist oppdatert Onsdag 6. oktober, 2021 - 17:45
Forskere: Marit Kolby og Inge A. Lindseth.
Abstract
A diet high in ultra-processed foods promotes inflammation that arises from both structural and behavioral changes in the resident microbiome. The environment created in the gut by ultra-processed foods is an evolutionarily unique selection ground for microbes that can promote diverse forms of inflammatory disease. Recognizing the importance of the microbiome in the development of diet-related disease has implications for future research, public dietary advice as well as food production practices. Research into food patterns suggests that whole foods are a common denominator of diets associated with a low level of diet-related disease. Hence, by studying how ultra-processing changes the properties of whole foods and how these foods affect the gut microbiome, more useful dietary guidelines can be made. Innovations in food production should be focusing on enabling health in the super-organism of man and microbe, and stronger regulation of potentially hazardous components of food products is warranted.
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This article won the 2020 Best paper prize from the journal, due to high citations and novelty: https://www.mdpi.com/journal/nutrients/awards/1132